Vortioxetine Impurity 13

Vortioxetine Impurity 13 - Names and Identifiers

Name	1-(2-BROMOPHENYL)PIPERAZINE
Synonyms	9-METHYLBENZOTRIAZOLE Vortioxetine impurity B Vortioxetine Impurity 13 1-(2-BROMOPHENYL)PIPERAZINE 1-(2-BROMOPHENYL)-PIPERAZINE Piperazine, 1-(2-bromophenyl)- 1- (2- bromine phenyl) piperazine
CAS	1011-13-8
EINECS	673-619-2
InChI	InChI=1/C10H13BrN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2

Vortioxetine Impurity 13 - Physico-chemical Properties

Molecular Formula	C10H13BrN2
Molar Mass	241.13
Density	1.386±0.06 g/cm3(Predicted)
Boling Point	94-96°C/0.02mm
Flash Point	157.6°C
Vapor Presure	0.000108mmHg at 25°C
pKa	8.80±0.10(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.575

Vortioxetine Impurity 13 - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

Vortioxetine Impurity 13 - Introduction

1-(2-Bromophenyl) piperazine is an organic compound with the chemical formula C12H10BrN. The following is a description of its nature, use, preparation and safety information:

Nature:
1-(2-Bromophenyl) piperazine is a solid with a white crystalline appearance. It has a melting point of about 140-142°C and a boiling point of about 317°C. It is almost insoluble in water at normal temperature, but soluble in organic solvents (e. g., ethanol, chloroform).

Use:
1-(2-Bromophenyl) piperazine is an important intermediate compound, which is often used in organic synthesis. It is often used in the pharmaceutical industry as a raw material for the synthesis of drugs, especially certain antipsychotic and sedative drugs, such as benzodiazepines.

Preparation Method:
The preparation method of 1-(2-bromophenyl) piperazine is usually obtained by reacting p-piperazine with bromobenzene. First, piperazine is reacted with bromobenzene under alkaline conditions, and then after crystallization, separation and purification, the target product is finally obtained.

Safety Information:
1-(2-Bromophenyl) piperazine generally does not cause serious harm under normal conditions of use. However, it is an organic compound with certain toxicity. Appropriate safety precautions should be taken during use or handling to avoid skin contact, inhalation or ingestion. In the use of the process should comply with the operating procedures, wear protective gloves, glasses and protective masks. In case of accidental contact, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 21:01:54